Category
Sexual health
Peptides acting on brain-level arousal, bonding and reproductive-hormone pathways rather than local blood flow. A genuinely different mechanism class from PDE5 inhibitors like sildenafil.
Category primer
PT-141 is the only compound here with a real FDA approval, for HSDD in women. Oxytocin has decades of academic research behind its social/bonding effects, and a real replication-crisis history worth knowing about. Kisspeptin has unusually rigorous, if small-scale and acute-dosing, academic research behind it, more than most peptides discussed here for off-label use.
PEPTIDES in this category
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Gonadorelin acetate
GnRH agonist peptide that stimulates endogenous LH and FSH to preserve testicular function and fertility during testosterone replacement therapy.
FDA approved -
Human Chorionic Gonadotropin
Placental hormone that mimics LH to stimulate testicular testosterone production and sperm output. Used clinically for hypogonadism/fertility, off-label in TRT, and in doping.
FDA approved -
Kisspeptin
The master upstream regulator of the reproductive hormone axis, more recently studied for direct effects on sexual and emotional brain processing, not just downstream hormone levels.
Investigational -
Melanotan II
Unregulated synthetic melanocortin agonist used illicitly for tanning and erectile function, with significant cardiovascular and melanoma safety concerns.
Research chemical -
Ovagen
Organ-targeted peptide supporting ovarian tissue function and reproductive health.
Approved in Russia; veterinary research applications documented -
Oxytocin
The 'bonding hormone' — an FDA-approved drug for labor induction and postpartum hemorrhage, explored off-label for social bonding, sexual intimacy and anxiety.
FDA-approved (obstetric use) -
Prostamax
Organ-targeted peptide bioregulator designed to support prostate tissue structure and urogenital function.
Approved in Russia -
PT-141 (Bremelanotide)
A melanocortin-receptor agonist that acts on the brain's sexual-arousal pathways rather than on blood flow directly — FDA-approved as Vyleesi for hypoactive sexual desire disorder in premenopausal women, used off-label by men for erectile/libido support.
FDA-approved (women's HSDD) -
Testagen
Testis-targeted bioregulator peptide from the Khavinson family, proposed for testicular and vascular function.
Experimental research compound