Testosterone cypionate
Long-acting testosterone ester, half-life around eight days, which is why weekly or twice-weekly injection is typical.
Medications & hormones
Research records
Historical source snapshot. Not freshly verified, not a recommendation. Study findings, community accounts and app defaults are not interchangeable.
Publication suitability · 2026-10-15: Historical reference only; not a clinical verification. Clinical, regulatory, efficacy, safety and dose claims are not independently established by this review.
Testosterone cypionate
Long-acting testosterone ester, half-life around eight days, which is why weekly or twice-weekly injection is typical.
Evidence category: Regulator / guideline. This describes the source category, not approval or certainty.
Regulatory statement in source: FDA-approved.
Testosterone cypionate is an injectable testosterone ester with an FDA-approved label (Depo-Testosterone). The label approves it as replacement therapy in men with primary hypogonadism or hypogonadotropic hypogonadism. It states that safety and efficacy in age-related (late-onset) hypogonadism have not been established. It is contraindicated in men with known or suspected prostate or breast cancer.
Benefits reported in the imported source
- Replacement therapy in men with primary or hypogonadotropic hypogonadism.
Risks and limits
- The label states safety and efficacy in age-related hypogonadism are not established.
- Contraindicated in men with known or suspected prostate or breast cancer.
Source bottom line: Testosterone cypionate is FDA-approved for diagnosed hypogonadism; age-related decline sits outside the label.
Uncertainty: Reference information only. Not medical advice.
Study protocols — reports, not instructions
men with primary hypogonadism or hypogonadotropic hypogonadism, per the US label
- Reported regimen
- 50-400 mg by deep intramuscular injection into the gluteal muscle every two to four weeks
- Duration
- ongoing, per the label
- Reported outcome
- The label approves this dosing as replacement therapy, and states safety and efficacy in age-related hypogonadism have not been established.
- Source
- Depo-Testosterone (testosterone cypionate injection) FDA Label
Claim provenance
evidence.json#/catalog:hormone:testosterone-cypionate/protocols/0
Community and practice descriptions
Accounts of a practice are not evidence of safety or effectiveness. Words such as “standard”, “safe” or “recommended” describe the source account, not verified consensus or this wiki’s advice. Commercial and self-published citations are retained for traceability, not vendor endorsement or independent clinical corroboration.
Unverified imported account — Testosterone Cypionate Weekly Injection Protocol
An imported authored paraphrase, not a quotation or a recommended protocol.
Review: population and route limited. The first community citation is a clinical article, not a community dosing guideline. Its study population and route must not be generalised to the imported claim of standard intramuscular TRT dosing. The imported wording is preserved for attribution; its full clinical, dosing, efficacy or consensus claims have not been independently established. Unvalidated source account; no validated human dosing population or animal-to-human equivalence is inferred.
Imported wording: Clinical and community guidelines reference 100-200 mg testosterone cypionate administered weekly via intramuscular injection as standard TRT dosing.
Unverified imported account — Forms of Testosterone Replacement - BowTiedLoon's Newsletter
An imported authored paraphrase, not a quotation or a recommended protocol.
Review: population and route limited. The first community citation is a clinical article, not a community dosing guideline. Its study population and route must not be generalised to the imported claim of standard intramuscular TRT dosing. The imported wording is preserved for attribution; its full clinical, dosing, efficacy or consensus claims have not been independently established. Unvalidated source account; no validated human dosing population or animal-to-human equivalence is inferred.
Imported wording: A user forum discussion describes a protocol of approximately 100-150 mg testosterone cypionate administered once weekly for TRT, noted as a standard practice among TRT clinicians.
Forms of Testosterone Replacement - BowTiedLoon's Newsletter
Pharmacokinetic context
Historical half-life estimate: 144–192 hours. FDA label, Depo-Testosterone Population/route context and estimates may differ. This is not a schedule or a verified human dosing rule.
Source references
Snapshot provenance
Source ID: catalog:hormone:testosterone-cypionate. Commit: adc7684614f9439b41d91a3312b62e7982c7e20e. Review state: historical-not-reverified. Authored links are retained separately from the canonical evidence links in the public data. App templates/defaults and rejected drafts are archived, not deployed.
Related entries and components
None listed.