Category
Nootropics & cognitive
Peptides from the Russian 'peptide bioregulator' research tradition, several with genuine domestic drug approval in Russia, used elsewhere off-label for focus, mood and sleep.
Category primer
Semax and Selank both hold real Russian drug approvals and dedicated clinical trials, genuinely more than most compounds on this wiki, but that evidence base has had less independent international replication than Western regulatory review typically requires. DSIP is the weakest-evidenced member of this category despite the name.
PEPTIDES in this category
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Cerebrolysin
Porcine neuropeptide preparation with clinical use for stroke and dementia in non-US countries.
Approved in 40+ countries; not FDA-approved in US -
Cortagen
Organ-targeted Khavinson peptide aimed at cerebral cortex structure and cognitive function.
Approved in Russia -
DSIP
A short peptide first isolated from the brains of sleeping rabbits, explored for sleep, stress and pain modulation. Human evidence for an actual sleep-inducing effect is thin, despite the name.
Research chemical -
FGL(L)
A 15-amino-acid fragment of the neural cell adhesion molecule that activates FGFR1 in rodent brains — real synaptic-plasticity data, zero human trials.
Research chemical -
P21
CNTF-derived peptide with claimed neurogenic potential; adamantane-conjugated variant designed for blood-brain barrier penetration.
Investigational research compound -
PE 22-28
Engineered spadin analog with improved TREK-1 channel inhibition and fast-acting antidepressant properties.
Research chemical -
Pinealon
Pineal-derived peptide bioregulator with cognitive and neuroprotective positioning.
Available in Russia and some international suppliers -
Selank
Russian-developed anxiolytic peptide, approved as a prescription drug in Russia for anxiety and mixed anxiety-depressive disorders. Used off-label elsewhere as a calming nasal-spray nootropic.
Approved in Russia -
Semax
Russian-developed nootropic peptide, approved as a prescription drug in Russia for stroke recovery and cognitive/attention support. Widely used off-label elsewhere as a nasal-spray nootropic.
Approved in Russia -
VIP
Endogenous neuropeptide and vasodilator with immunomodulatory properties, used investigationally for mold-illness immune dysregulation and pulmonary hypertension.
FDA investigational (synthetic aviptadil had Fast Track status for COVID-19, not approved)
POPULAR stacks in this category
- Semax + Selank — Russian nootropic paired with a Russian anxiolytic.