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Peptide bioregulators

Cortagen

Organ-targeted Khavinson peptide aimed at cerebral cortex structure and cognitive function.

Approved in Russia Peptide bioregulators Nootropics & cognitive

Reviewed 2026-09-12
Full name
Cortagen (Ala-Glu-Asp-Pro, brain cortex peptide)
Also known as
AEDP
Regulatory status
Approved in Russia

Origin

Synthesized from the amino-acid composition of a natural cerebral-cortex peptide extract related to Cortexin, derived from bovine brain-cortex tissue preparations, approved in Russia as injectable and oral formulations.

Mechanism

Proposed to regulate cerebral cortex cell differentiation and reduce brain oxidative stress, with suggested effects on neurotrophic factor expression and circadian melatonin regulation in aging models.

Research summary

Evidence

A 2007 study documented antioxidant effects and reduced oxidative-stress markers in rat cerebral cortex; earlier organotypic culture work established tissue-specific effects. Research comes almost entirely from Khavinson's group, and no human trials appear in English-language literature.

Evidence tier: Approved in Russia — see the methodology note for how this is assessed.

Citations

Reported benefits

  • support for cortical cell renewal (preclinical)
  • potential reduction in brain oxidative stress
  • claimed cognitive/neuroprotective support

Dosing protocols reported in the literature & community

These are protocols reported by compounding pharmacies, published trials, or self-experimentation communities — not a prescription. Start low, especially for anything new.

Reported dosing protocols
RouteReported protocol
Subcutaneous/intramuscular injection or oral tabletCommunity dosing: 10-20 mg subcutaneously or intramuscularly; oral forms 10-30 mg; no validated human protocol.

Side effects

  • minimal reported; neurological monitoring data unavailable

Safety notes

Safety: No serious adverse events reported in Russian studies, but CNS effects are poorly characterized in humans, and long-term safety is undocumented.
Community & reddit notes (anecdotal — not clinical evidence)

Discussed in Western nootropics and longevity communities for mental clarity and cognitive aging support. The evidence base is minimal and largely inaccessible to Western practitioners.