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Fitness & muscle

GHRP-2

Potent synthetic growth hormone secretagogue with strong GH stimulation and emerging research support for tissue repair.

Research compound Fitness & muscle Recovery & healing

Reviewed 2026-09-12
Full name
Growth hormone releasing peptide-2 (pralmorelin)
Also known as
pralmorelin, GPA-748
Regulatory status
Research compound | Used experimentally in clinical settings

Origin

Synthetic hexapeptide GH secretagogue mimicking ghrelin, INN pralmorelin. Originally developed for diagnostic testing of pituitary GH reserve.

Mechanism

Potent agonist of GHSR1a on anterior pituitary somatotrophs, stimulating rapid GH release via Gq/11 signaling. Recent research suggests immune-modulation and tissue-repair effects independent of GH.

Research summary

Evidence

Produces robust GH responses (peak >80 ng/mL) in diagnostic use. Animal studies show improved tendon-bone healing in rotator cuff models through macrophage modulation. Clinical applications remain limited to diagnostic testing; long-term data in non-clinical populations is sparse.

Evidence tier: Research compound — see the methodology note for how this is assessed.

Citations

Reported benefits

  • growth hormone stimulation
  • tendon/ligament healing
  • reduced inflammation (animal models)
  • muscle recovery

Dosing protocols reported in the literature & community

These are protocols reported by compounding pharmacies, published trials, or self-experimentation communities — not a prescription. Start low, especially for anything new.

Reported dosing protocols
RouteReported protocol
Subcutaneous injection100-200 mcg once or twice daily; often stacked with other GHRPs or CJC-1295.

Side effects

  • appetite stimulation (mild)
  • cortisol elevation with repeated doses
  • prolactin elevation
  • numbness/tingling

Safety notes

Safety: Not approved for human use outside clinical research. Repeated dosing may raise prolactin/cortisol. Limited long-term safety data.
Community & reddit notes (anecdotal — not clinical evidence)

Used with CJC-1295 or ipamorelin as a peptide stack. Anecdotal reports of improved recovery and faster minor-injury healing.

Mixing compatibility

Pulled from a community-charted mixing-compatibility reference (anecdotal, clinic-use, and community-reported signals) — not a safety guarantee. Verify independently before combining anything.

Used together in wellness-clinic protocols

Reported as a combination to avoid