Peptide stack
BPC-157 + TB-500 + GHK-Cu
The base recovery stack plus a collagen-remodeling peptide.
Also known as: GLOW stack
Components studied separately, not the combination
COMPONENTS in this stack
-
BPC-157
A 15-amino-acid fragment of the gastric body-protection compound, the most widely self-administered healing peptide for tendon, ligament, muscle, and gut injuries.
Research chemical -
TB-500 / Thymosin Beta-4
A naturally occurring wound-response peptide released by platelets, used for muscle, tendon and neurological healing, often stacked with BPC-157.
Research chemical -
GHK-Cu
A naturally occurring copper-binding tripeptide found in human plasma. The best-studied skin peptide, also investigated for wound healing, hair and connective tissue.
Cosmetic (topical) / off-label injectable
Why these are combined
BPC-157 for systemic healing, TB-500 for angiogenesis and fibroblast migration, GHK-Cu for collagen synthesis and tissue remodeling. Each has its own wound-healing evidence, but nobody has tested the three together, so any added benefit from combining them is assumed, not measured.
Mechanism & pharmacokinetics
Adds a third, mechanistically separate pathway to the BPC-157/TB-500 base: GHK-Cu acts through copper-dependent modulation of matrix metalloproteinases and direct effects on collagen and fibroblast gene expression, distinct from BPC-157's growth-factor-receptor route and TB-500's actin-binding route. Like the other two, GHK-Cu clears from plasma quickly, but its reported effects (collagen remodeling, wound-site gene expression changes) are described as outlasting its circulating presence, similar in shape to TB-500's profile. Because none of the three peptides are reported to compete for the same receptor or enzyme system, the theoretical case against pharmacodynamic interference is reasonable — but again, nobody has run the three-way combination as a study; this is inference from three separate evidence bases, not a tested one. The 'GLOW' name reflects the cosmetic/skin angle GHK-Cu adds on top of the base recovery stack, not a literal acronym of the ingredients.
Citations
- Biomimetic Hydrogel Scaffolds with Copper Peptide-Functionalized RADA16 Nanofiber Improve Wound Healing in Diabetes — Yang et al. 2022
- GHK and DNA: resetting the human genome to health — Pickart et al. 2014
- Exploring the Role of Tripeptides in Wound Healing and Skin Regeneration: A Comprehensive Review — Adnan et al. 2025
Typical community protocol
BPC-157 250-500 mcg daily, TB-500 2-4 mg weekly, GHK-Cu 200-300 mcg 3-4x weekly. Commonly run 8-12 weeks, subcutaneous injection.
Safety notes
Community notes (anecdotal — not clinical evidence)
Called the 'full healing stack' in recovery forums. Popular for post-injury and post-surgical use despite zero trial data on the three-way combination.