Magnesium
Mineral supplement. Glycinate and citrate are the commonly used forms; oxide is poorly absorbed.
Supplements
Research records
Historical source snapshot. Not freshly verified, not a recommendation. Study findings, community accounts and app defaults are not interchangeable.
Publication suitability · 2026-10-15: Historical reference only; not a clinical verification. Clinical, regulatory, efficacy, safety and dose claims are not independently established by this review.
Magnesium
Mineral supplement. Glycinate and citrate are the commonly used forms; oxide is poorly absorbed.
Evidence category: Clinical study. This describes the source category, not approval or certainty.
Regulatory statement in source: Not separately recorded; do not infer approval from the evidence category.
Magnesium is an essential mineral; the NIH Office of Dietary Supplements fact sheet is a general reference on intake, status and tolerance. A 24-week randomised, double-blind, placebo-controlled trial in 164 adults found that magnesium citrate, oxide and sulfate did not change arterial stiffness or blood pressure, although citrate raised blood and urine magnesium most. A rat study found that different organic forms reach different tissues, with behaviour changes in animals. No human trial here shows an anxiety or blood-pressure benefit.
Benefits reported in the imported source
- Magnesium is an essential mineral, with the NIH fact sheet as a general reference.
- In a randomised trial, citrate raised blood and urine magnesium more than the other forms.
Risks and limits
- No human trial here shows an anxiety or blood-pressure benefit.
- A randomised trial in 164 adults found no change in arterial stiffness or blood pressure.
- Differences between forms were shown only in rats, where vascular relaxation was diminished.
Source bottom line: Magnesium is an essential mineral; the human trial here found no blood pressure or arterial stiffness effect.
Uncertainty: Reference information only. Not medical advice.
Study protocols — reports, not instructions
164 overweight and slightly obese adults, mean age 63.2, 63% women
- Reported regimen
- 450 mg of magnesium a day as citrate, oxide or sulfate, or placebo, randomised and double-blind
- Duration
- 24 weeks
- Reported outcome
- No change in carotid-to-femoral pulse wave velocity or blood pressure for any formulation; citrate raised plasma and 24-hour urinary magnesium most.
- Source
- Effects of Magnesium Citrate, Magnesium Oxide, and Magnesium Sulfate Supplementation on Arterial Stiffness: A Randomized, Double-Blind, Placebo-Controlled Intervention Trial (Schutten et al. 2022)
Claim provenance
evidence.json#/catalog:supplement:magnesium/protocols/0
38 adult Sprague Dawley rats in four groups (control, citrate, glycinate, malate)
- Reported regimen
- 35.4 mg/kg/day of elemental magnesium as citrate, glycinate or malate by oral gavage once daily; controls got tap water the same way
- Duration
- 8 weeks
- Reported outcome
- Citrate and glycinate shortened water-maze escape latency, malate improved grip strength; the elevated plus maze showed no difference and vascular relaxation was diminished.
- Source
- Chronic Organic Magnesium Supplementation Enhances Tissue-Specific Bioavailability and Functional Capacity in Rats: A Focus on Brain, Muscle, and Vascular Health (availability check 2026-10-15: possible access barrier; not independently inspected; HTTP 200)
Claim provenance
evidence.json#/catalog:supplement:magnesium/protocols/1
Community and practice descriptions
Accounts of a practice are not evidence of safety or effectiveness. Words such as “standard”, “safe” or “recommended” describe the source account, not verified consensus or this wiki’s advice. Commercial and self-published citations are retained for traceability, not vendor endorsement or independent clinical corroboration.
Historical research outcome: no-verified-description · 2026-10-06
No suitable community description was independently verified in these checks. The entry remains empty; this does not establish that no practice exists elsewhere. The excerpt only lists food and medicinal product sources, not a community supplementation routine.
- https://nutritionsource.hsph.harvard.edu/magnesium/: no-practice-description — The excerpt only lists food and medicinal product sources, not a community supplementation routine.
Pharmacokinetic context
No half-life recorded in this source snapshot. No value has been inferred.
Source references
- Office of Dietary Supplements - Magnesium (Health Professional Fact Sheet) (availability check 2026-10-15: source not retrieved; HTTP 403)
- Effects of Magnesium Citrate, Magnesium Oxide, and Magnesium Sulfate Supplementation on Arterial Stiffness: A Randomized, Double-Blind, Placebo-Controlled Intervention Trial (Schutten et al. 2022)
- Chronic Organic Magnesium Supplementation Enhances Tissue-Specific Bioavailability and Functional Capacity in Rats: A Focus on Brain, Muscle, and Vascular Health (availability check 2026-10-15: possible access barrier; not independently inspected; HTTP 200)
- NIH ODS: Magnesium (availability check 2026-10-15: source not retrieved; HTTP 403)
Snapshot provenance
Source ID: catalog:supplement:magnesium. Commit: adc7684614f9439b41d91a3312b62e7982c7e20e. Review state: historical-not-reverified. Authored links are retained separately from the canonical evidence links in the public data. App templates/defaults and rejected drafts are archived, not deployed.
Related entries and components
None listed.